· The producers originally wanted Matthew Broderick to play Alex P. Keaton, but the actor had to decline the role when his father became terminally ill.
· Alex's hero is Richard Nixon. Skippy (the perpetual Alex wanna-be) admired 'Gerald Ford'.
· Ed O'Neill was considered for the role of Steven Keaton.
· The show was modeled after producer Gary David Goldberg and wife Diane's real-life experiences as former 'hippies' transforming into suburban family life
· According to Michael J. Fox's last "Spin City" (1996) episode, Alex P. Keaton became a Junior Congressman from Ohio.
· Elyse's maiden name was Donelly.
· Alex was born in Africa when Elyse and Steven were serving in the Peace Corps.
· Jennifer was born on Election Day 1972.
· Alex attended Leland University.
· The character 'Steven Keaton' was ranked #12 in TV Guide's list of the "50 Greatest TV Dads of All Time" (20 June 2004 issue).
· Throughout the series' run, exterior establishment shots of the Keaton home were never used in any of the episodes, which is very unusual for a family sitcom. The vast majority of all scenes were played out in the kitchen.
· In March 2008, creator Gary David Goldberg wrote an essay for The New York Times speculating about what Alex Keaton's political beliefs would be now. Goldberg said that Keaton, as a "true Conservative Republican," would probably no longer feel comfortable in the Republican Party of the late 2000s, "a party whose legacy will include Terri Schiavo and Hurricane Katrina, [and]...waging war against science." Goldberg said that Keaton would have supported McCain in 2000 but no obvious candidate in the 2008 race. He also said that he and Michael J. Fox have different ideas about Keaton's current career; Goldberg thinks Keaton is a pro bono lawyer for the Children's Defense Fund, while Fox believes Keaton is finishing a prison sentence.